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Key:ODUOJXZPIYUATO-UHFFFAOYSA-N N N Y Racecadotril, also known as acetorphan, is an drug which acts as a peripherally acting. Unlike other medications used to treat diarrhea, which, racecadotril has an effect—it reduces the secretion of water and into the intestine. It is available in (where it was first introduced in ~1990) and other European countries (including,, the,, and the ) as well as most of South America and some countries (including, and ), but not in the United States. It is sold under the tradenames Hidrasec or, in France, Tiorfan. In Italy it is sold under the tradename Tiorfix.
In India it's available as Redotril. Is the active metabolite of racecadotril, which exerts the bulk of its inhibitory actions on enkephalinase. Contents • • • • Pharmacokinetics [ ] Racecadotril is rapidly absorbed after oral administration and doses of 30 mg, 100 mg and 300 mg reached Cmax within 60 min.
Food does not affect bioavailability of racecadotril. Racecadotril is rapidly and effectively metabolized to the active metabolite thiorphan which inhibits enkephainase enzyme and exhibits anti-secretory effect. Medical uses [ ] Racecadotril can be used for treatment of acute diarrhea patients and has better tolerability than loperamide.
Several guidelines have recommended racecadotril use in addition to oral rehydration treatment in children with acute diarrhea. See also [ ] •, the ( S)-enantiomer of racecadotril • • References [ ]. • Agonists (abridged; see for a full list): • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • () • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • PAMs: • • Antagonists: • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Unknown/unsorted: • • • • •.